Acidosis, cardiac stunning and its prevention by oxygen.
Cell Biol Int Rep
; 14(4): 311-5, 1990 Apr.
Article
em En
| MEDLINE
| ID: mdl-2354521
ABSTRACT
When during aerobic perfusion of the 5 Hz paced rat Langendorff heart, under constant aortic pressure of 8.3 kPa, the pH of the medium is changed from 7.5 to 7.0 a short period of positive inotropy is followed by a dramatic loss of contractility. The hearts, rapidly frozen after 10 min pH 7.0 perfusion, show moderate loss of high-energy phosphates and accumulation of lactate and glycerol-3-phosphate, indicative of tissue anaerobiosis. This can be overcome by including fluorocarbon, an O2 vehicle, in the media. The transient positive inotropy is interpreted as H(+)-induced release of plasmalemma-bound Ca2+ into the cytosol. The accompanying morphologic alterations are as described in this issue by Vandeplassche and Borgers (1990) and by Verkleij et al. (1990).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Acidose
/
Coração
Limite:
Animals
Idioma:
En
Revista:
Cell Biol Int Rep
Ano de publicação:
1990
Tipo de documento:
Article