Immune system, cell senescence, aging and longevity--inflamm-aging reappraised.
Curr Pharm Des
; 19(9): 1675-9, 2013.
Article
em En
| MEDLINE
| ID: mdl-23589904
ABSTRACT
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm-aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Senescência Celular
/
Sistema Imunitário
/
Inflamação
/
Longevidade
Limite:
Humans
Idioma:
En
Revista:
Curr Pharm Des
Ano de publicação:
2013
Tipo de documento:
Article