New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies.
Future Oncol
; 9(5): 681-97, 2013 May.
Article
em En
| MEDLINE
| ID: mdl-23647297
ABSTRACT
The hedgehog (Hh) pathway is a critical regulator of vertebrate embryonic development and is involved in the function of processes such as stem cell maintenance and differentiation, tissue polarity and cell proliferation. Given how critical these functions are, it is not surprising that mutations in Hh pathway components are often implicated in the tumorigenesis of a variety of human cancers. Promotion of tumor growth has recently been shown by activated Hh signaling in the tumor itself, as well as by pathway activation within surrounding cells comprising the tumor microenvironment. Targeted disruption of various Hh pathway proteins has been successfully employed as an anticancer strategy with several synthetic Hh antagonists now available. Here, the molecular basis of Hh signaling, the therapeutic rationales for targeting this pathway and the current status of Hh pathway inhibitors in the clinic are reviewed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
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Neoplasias Hematológicas
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Proteínas Hedgehog
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Terapia de Alvo Molecular
Limite:
Humans
Idioma:
En
Revista:
Future Oncol
Ano de publicação:
2013
Tipo de documento:
Article