Role of nuclear factor kappa-B in phenytoin-induced gingival overgrowth.
Oral Dis
; 20(3): 294-300, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-23651365
ABSTRACT
OBJECTIVE:
This study investigates the expression of transcription factor nuclear factor-kappa B (NF-κB) and its relation to various cellular mediators that act in the pathogenesis of phenytoin-induced gingival overgrowth. MATERIALS ANDMETHODS:
Eighteen epileptic patients had phenytoin-induced gingival overgrowth (PHT-GO), 20 patients with plaque-induced gingivitis (Gingivitis), and 20 periodontally and systemically healthy individuals (Control) were included in this study. The expression of activated NF-κB subunits (p50 and p65), IL-1ß, TNF-α and TGFß-1 levels were examined in the gingival sections obtained from each participant.RESULTS:
The results demonstrated a significantly higher expression of p65 in fibroblasts in PHT-GO group with respect to Gingivitis (P < 0.05) and control groups (P < 0.01). However, we found no statistically significant differences between PHT-GO and Gingivitis groups according to the immunohistochemical staining in macrophages (P > 0.05). Immune-reactive TGFß-1 levels in the gingival connective tissue cells were statistically higher in PHT-GO group with respect to Gingivitis group(P < 0.05). Statistically significant correlations were found between the HI and activated TGFß-1 and p65 levels in PHT-GO group.CONCLUSION:
The results of this study showed that NF-κB is activated in PHT-related gingival overgrowth. This study may provide a basis for future research into specific NF-κB inhibition for preventing of the side effects of this drug.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenitoína
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NF-kappa B
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Crescimento Excessivo da Gengiva
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Gengivite
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Anticonvulsivantes
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Oral Dis
Ano de publicação:
2014
Tipo de documento:
Article