Asymmetric synthesis of indole homo-Michael adducts via dynamic kinetic Friedel-Crafts alkylation with cyclopropanes.

Wales, Steven M; Walker, Morgan M; Johnson, Jeffrey S

Wales, Steven M; Walker, Morgan M; Johnson, Jeffrey S.

Afiliação

Wales SM; Department of Chemistry, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599-3290, United States.

Org Lett ; 15(10): 2558-61, 2013 May 17.

Article em En | MEDLINE | ID: mdl-23654283

ABSTRACT

ABSTRACT

An enantioconvergent Friedel-Crafts alkylation of indoles with donor-acceptor cyclopropanes is described. The reaction is catalyzed by pyboxâ¢MgI2 and proceeds via a type I dynamic kinetic asymmetric transformation (DyKAT).

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Ano de publicação: 2013 Tipo de documento: Article

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Org Lett Ano de publicação: 2013 Tipo de documento: Article