Neurotrophins play differential roles in short and long-term recognition memory.
Neurobiol Learn Mem
; 104: 39-48, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23669064
ABSTRACT
The neurotrophin family of proteins are believed to mediate various forms of synaptic plasticity in the adult brain. Here we have assessed the roles of these proteins in object recognition memory in the rat, using icv infusions of function-blocking antibodies or the tyrosine kinase antagonist, tyrphostin AG879, to block Trk receptors. We report that tyrphostin AG879 impairs both short-term and long-term recognition memory, indicating a requirement for Trk receptor activation in both processes. The effect of inhibition of each of the neurotrophins with activity-blocking neutralising antibodies was also tested. Treatment with anti-BDNF, anti-NGF or anti-NT4 had no effect on short-term memory, but blocked long-term recognition memory. Treatment with anti-NT3 had no effect on either process. We also assessed changes in expression of neurotrophins and their respective receptors in the hippocampus, dentate gyrus and perirhinal cortex over a 24 h period following training in the object recognition task. We observed time-dependent changes in expression of the Trk receptors and their ligands in the dentate gyrus and perirhinal cortex. The data are consistent with a pivotal role for neurotrophic factors in the expression of recognition memory.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Memória de Longo Prazo
/
Memória de Curto Prazo
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Fatores de Crescimento Neural
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Learn Mem
Ano de publicação:
2013
Tipo de documento:
Article