[The advance in synthetic biology: towards a microbe-derived paclitaxel intermediates].
Yao Xue Xue Bao
; 48(2): 187-92, 2013 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-23672014
ABSTRACT
The synthetic biology matures to promote the heterologous biosynthesis of the well-known drug paclitaxel that is one of the most important and active chemotherapeutic agents for the first-line clinical treatment of cancer. This review focuses on the construction and regulation of the biosynthetic pathway of paclitaxel intermediates in both Escherichia coli and Saccharomyces cerevisiae. In particular, the review also features the early efforts to design and overproduce taxadiene and the bottleneck of scale fermentation for producing the intermediates.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Paclitaxel
/
Diterpenos
/
Alcenos
/
Escherichia coli
/
Biologia Sintética
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2013
Tipo de documento:
Article