[Inflammasome--essential regulator of the inflammatory reaction]. / Inflammasomi--tulehdusreaktion keskeinen säätelijä.
Duodecim
; 129(7): 705-11, 2013.
Article
em Fi
| MEDLINE
| ID: mdl-23720939
The function of inflammasome in the cell is to sense intracellular danger signals and--perhaps as the last cry of distress of a cell invaded by a microorganism--at an emergency situation to release interleukins (IL) outside of the cell, causing an inflammatory reaction and fever and also leads to an elevation of CRP. In a hopeless situation inflammasome-regulated pyroptosis is started. Disturbed action of inflammasomes has been linked to the pathogenesis of various disorders such as gout, atherosclerosis, asbestosis and type 2 diabetes. As the pathogenetic mechanisms of such diseases become clear, improved treatments for them may also become available.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inflamassomos
Limite:
Humans
Idioma:
Fi
Revista:
Duodecim
Ano de publicação:
2013
Tipo de documento:
Article