Chemical constituents of Swertia yunnanensis and their anti-hepatitis B virus activity.
Fitoterapia
; 89: 175-82, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23747320
ABSTRACT
Four new triterpenoids, sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4), along with nineteen known compounds (5-23) were isolated from Swertia yunnanensis. Based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, UV, IR, [α]D), the structures of sweriyunnangenin A (1), sweriyunnanosides A (2), B (3) and C (4) were elucidated as taraxer-14-ene-3α,6ß-diol, oleanolic acid 28-O-ß-D-glucopyranosyl-(1â2)-O-ß-D-glucopyranoside, 2α,3ß-di-hydroxyolean-12-en-28-oic acid 28-O-ß-D-glucopyranosyl(1â6)-ß-D-glucopyranosyl (1â6)-ß-D-glucopyranosyl(1â2)-ß-D-glucopyranoside and hederagenin 28-O-ß-D-glucopyranosyl(1â6)-ß-D-glucopyranosyl(1â6)-ß-D-glucopyranosyl(1â2)-ß-D-glucopyranoside, respectively. Twenty-two compounds were evaluated for their anti-HBV activities on the HepG 2.2.15 cell line in vitro, of which nine compounds showed potent anti-HBV activities. Compounds 1, 5-6, 14-16 and 19 showed activities against the secretion of HBsAg (IC50 values from 0.10 to 1.76 mM) and HBeAg (IC50 values from 0.04 to 1.41 mM), and compounds 11 and 13-16 exhibited significant inhibition on HBV DNA replication (IC50 values from 0.01 to 0.09 mM).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
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Triterpenos
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Extratos Vegetais
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Vírus da Hepatite B
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Swertia
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Glucosídeos
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Hepatite B
Limite:
Humans
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2013
Tipo de documento:
Article