[The dynamics of antibody formation to a vaccinal strain of Francisella tularensis in different immunization regimens]. / Dinamika obrazovaniia antitel k vaktsinnomu shtammu Francisella tularensis pri razlichnykh skhemakh immunizatsii.

ABSTRACT

The use of different schemes of albino mice immunization either by living or by killed preparations of the vaccine strain of Francisella tularensis when obtaining monoclonal antibodies to the tularemia microbe made it possible to reveal definite regularities in the dynamics of antibody formation. The highest titres of antibodies in sera of animals-donors of splenocytes were obtained during the daily (for 3 days) intraperitoneal immunization of mice with living vaccine or with its thrice administration to the spleen thrice with the interval of 10 days. Revaccination against a background of high titres of antibodies decreased their quantity in blood serum of mice, while that against a background of low titres increased them.