Long-term exposure to PM10 and NO2 in association with lung volume and airway resistance in the MAAS birth cohort.
Environ Health Perspect
; 121(10): 1232-8, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-23777813
ABSTRACT
BACKGROUND:
Findings from previous studies on the effects of air pollution exposure on lung function during childhood have been inconsistent. A common limitation has been the quality of exposure data used, and few studies have modeled exposure longitudinally throughout early life.OBJECTIVES:
We sought to study the long-term effects of exposure to particulate matter with an aerodynamic diameter ≤ 10 µm (PM10) and to nitrogen dioxide (NO2) on specific airway resistance (sR(aw)) and forced expiratory volume in 1 sec (FEV1) before and after bronchodilator treatment. Subjects were from the Manchester Asthma and Allergy Study (MAAS) birth cohort (n = 1,185).METHODS:
Spirometry was performed during clinic visits at ages 3, 5, 8, and 11 years. Individual-level PM10 and NO2 exposures were estimated from birth to 11 years of age through a microenvironmental exposure model. Longitudinal and cross-sectional associations were estimated using generalized estimating equations and multivariable linear regression models.RESULTS:
Lifetime exposure to PM10 and NO2 was associated with significantly less growth in FEV1 (percent predicted) over time, both before (-1.37%; 95% CI -2.52, -0.23 for a 1-unit increase in PM10 and -0.83%; 95% CI -1.39, -0.28 for a 1-unit increase in NO2) and after bronchodilator treatment (-3.59%; 95% CI -5.36, -1.83 and -1.20%; 95% CI -1.97, -0.43, respectively). We found no association between lifetime exposure and sR(aw) over time. Cross-sectional analyses of detailed exposure estimates for the summer and winter before 11 years of age and lung function at 11 years indicated no significant associations.CONCLUSIONS:
Long-term PM10 and NO2 exposures were associated with small but statistically significant reductions in lung volume growth in children of elementary-school age.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Resistência das Vias Respiratórias
/
Poluentes Atmosféricos
/
Material Particulado
/
Pulmão
/
Dióxido de Nitrogênio
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Environ Health Perspect
Ano de publicação:
2013
Tipo de documento:
Article