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Urine concentrations of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles spaniels.
Jacinto, A M L; Mellanby, R J; Chandler, M; Bommer, N X; Carruthers, H; Fairbanks, L D; Gow, A G.
Afiliação
  • Jacinto AM; Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Studies, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, Scotland, EH25 9RG.
J Small Anim Pract ; 54(8): 395-8, 2013 Aug.
Article em En | MEDLINE | ID: mdl-23859747
ABSTRACT

OBJECTIVES:

Xanthine urolithiasis and asymptomatic xanthinuria have been diagnosed in Cavalier King Charles spaniel dogs suggesting that primary xanthinuria may be a breed-related disorder, although its prevalence remains unclear. The hypothesis of this study was that asymptomatic xanthinuria is common in Cavalier King Charles spaniel dogs.

METHODS:

Free catch urine samples were collected from 35 client-owned Cavalier King Charles spaniel dogs and from 24 dogs of other breeds. The purine metabolites were measured by high-performance liquid chromatography. The urine ratios of xanthine/creatinine and hypoxanthine/creatinine were calculated and compared between the two groups of dogs.

RESULTS:

The urine concentrations of purine metabolites were not significantly different between the two groups and were very low in both. The urine concentrations of xanthine in all 35 Cavalier King Charles spaniel were markedly lower than in the previously reported case of xanthine urolithiasis in a UK Cavalier King Charles spaniel dog. CLINICAL

SIGNIFICANCE:

Asymptomatic xanthinuria was not detected in this UK Cavalier King Charles spaniel population. This data may be used as a reference for urinary purine metabolite concentrations in the dog.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / Hipoxantina / Xantina / Cães Tipo de estudo: Risk_factors_studies Limite: Animals País/Região como assunto: Europa Idioma: En Revista: J Small Anim Pract Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Úrico / Hipoxantina / Xantina / Cães Tipo de estudo: Risk_factors_studies Limite: Animals País/Região como assunto: Europa Idioma: En Revista: J Small Anim Pract Ano de publicação: 2013 Tipo de documento: Article