Anti-inflammatory and antinociceptive effects of hydroalcoholic extract from Pseudobombax marginatum inner bark from caatinga potiguar.
J Ethnopharmacol
; 149(2): 416-21, 2013 Sep 16.
Article
em En
| MEDLINE
| ID: mdl-23871809
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE The Pseudobombax marginatum (St Hil) Rob., Malvaceae, is mentioned in ethnobotanical studies. It is used as anti-inflammatory, for ulcers and gastritis, and back pain. To evaluate anti-inflammatory and antinociceptive activities a hydroalcoholic extract (HE) from inner bark was prepared. MATERIALS AND METHODS:
For the anti-inflammatory activity, carrageenan-induced paw edema and peritonitis models, and also myeloperoxidase assay were used. For the antinociceptiva activity acetic acid-induced writhing, hot plate and formalin tests were employed.RESULTS:
The HE extract exhibited an intense inhibition in carrageenan-induced edema model and also in myeloperoxidase activity at the doses of 100 and 300 mg/kg. The leukocyte migration into the peritoneal cavity was also inhibited at the doses of 30, 100 and 300 mg/kg. A similar profile was observed against acid-induced abdominal contortions and in formalin second phase test at the doses of 30 and 100 mg/kg, but this treatment did not affect the behavior of animals in the hot plate test.CONCLUSIONS:
The experimental data of the HE from Pseudobombax marginatum show anti-inflammatory and antinociceptiva activities, confirming the indication from traditional medicine; however further studies are required to define and isolate the active anti-inflammatory and antinociceptiva components from this active specie.Palavras-chave
ANOVA; APG; ASA; AUC; CEPA; COX; EDTA; FLONA; HE; Inflammation; MPO; NO; Nociception; PGE2; PGs; Pseudobombax marginatum; SISBIO; UMPO; acetylsalicylic acid; analysis of variance; area under curves; authorization system and information in biodiversity; cyclo-oxygenase; ethics committee for animal use in research; ethylenediaminetetraacetic acid; group phylogeny of angiosperms; hydroalcoholic extract; myeloperoxidase; national forest; nitric oxide; prostaglandin E2; prostaglandins; units of myeloperoxidase
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Peritonite
/
Extratos Vegetais
/
Malvaceae
/
Analgésicos
/
Anti-Inflamatórios
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2013
Tipo de documento:
Article