Your browser doesn't support javascript.
loading
In vivo lymph node mapping and pattern of metastasis spread in locally advanced mid/low rectal cancer after neoadjuvant chemoradiotherapy.
Farinella, E; Viganò, L; Fava, M C; Mineccia, M; Bertolino, F; Capussotti, L.
Afiliação
  • Farinella E; Department of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Largo Turati 62, 10129, Turin, Italy.
Int J Colorectal Dis ; 28(11): 1523-9, 2013 Nov.
Article em En | MEDLINE | ID: mdl-23877264
PURPOSE: The lymph node status is one of the strongest prognostic determinants in rectal cancers. After chemoradiotherapy (CRT), lymph nodes are difficult to detect. This study aims to evaluate the feasibility of lymph node mapping in the mesorectum after CRT to analyze the pattern of metastasis spread and to assess the reliability of blue dye injection in sentinel lymph node detection. METHOD: Ten patients with cN+ mid/low RCs after CRT were prospectively enrolled. The protocol scheduled intraoperative blue dye injection, surgery, and specimen examination with fat clearance technique. The mesorectum was divided into three equal "levels" (upper, middle, and lower); each level was divided into three equal "sectors" (right anterolateral, posterior, and left anterolateral). Lymph nodes were defined "small" if ≤5 mm. RESULTS: Two hundred seventy-six lymph nodes were retrieved in ten patients; 76.5 % were small lymph nodes. Six patients were pN+ (33 metastatic lymph nodes, 76 % small); small lymph node analysis upstaged one patient from N0 to N1 and four patients from N1 to N2. Metastasis distribution across sectors was continuous, without "skip sectors." The blue dye detected the sentinel lymph node in all patients; in half of the cases, it was out of the tumor sector. Blue dye identified 69.7 % of metastatic lymph nodes; its sensitivity decreased together with the metastatic deposit size (84 % macrometastases, 28.6 % micrometastases, 0 % occult tumor cells; p = 0.004). CONCLUSION: The fat clearance technique should be the standard pathological examination in patients with RCs after CRT; N staging was improved by small lymph node identification. Lymph node metastases have a continuous spread through mesorectal sectors. Blue dye injection is effective in sentinel lymph node detection.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Terapia Neoadjuvante / Quimiorradioterapia / Linfonodos / Metástase Linfática Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Int J Colorectal Dis Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Retais / Terapia Neoadjuvante / Quimiorradioterapia / Linfonodos / Metástase Linfática Limite: Aged / Aged80 / Humans / Male / Middle aged Idioma: En Revista: Int J Colorectal Dis Ano de publicação: 2013 Tipo de documento: Article