Effects of an intensive short-term diet and exercise intervention: comparison between normal-weight and obese children.
Am J Physiol Regul Integr Comp Physiol
; 305(5): R552-7, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-23883675
ABSTRACT
Lifestyle intervention programs currently emphasize weight loss secondary to obesity as the primary determinant of phenotypic changes. We examined whether the effects of a short-term lifestyle intervention program differ in normal-weight versus overweight/obese children. Nineteen overweight/obese (O; BMI = 33.6 ± 1.9 kg/m(2)) and 14 normal-weight (N; BMI = 19.9 ± 1.5 kg/m(2)) children participated in a 2-wk program consisting of an ad libitum high-fiber, low-fat diet and daily exercise (2-2.5 h). Fasting serum samples were taken pre- and postintervention for determination of lipids, glucose homeostasis, inflammatory cytokines, and adipokines. Only the O group lost weight (3.9%) but remained overweight/obese (32.3 ± 1.9 kg/m(2)). Both groups exhibited significant intervention-induced decreases (P < 0.05) in serum insulin (N 52.5% vs. O 28.1%; between groups, P = 0.38), homeostatic model assessment for insulin resistance (N 53.1% vs. O 28.4%, P = 0.43), leptin (N 69.3% vs. O 44.1%, P = 0.10), amylin (N 28.7% vs. O 26.1%, P = 0.80), resistin (N 40.0% vs. O 35.1%, P = 0.99), plasminogen activator-inhibitor-1 (N 30.8% vs. O 25.6%, P = 0.59), IL-6 (N 58.8% vs. O 48.5%, P = 0.78), IL-8 (N 46.0% vs. O 42.2%, P = 0.49), and TNFα (N 45.8% vs. O 40.8%, P = 0.99). No associations between indices of weight change and phenotypic changes were noted. A short-term, intensive lifestyle modification program is effective in ameliorating metabolic risk factors in N and O children. These results suggest that obesity per se was not the primary driver of the phenotypes noted and that dietary intake and physical inactivity induce the phenotypic abnormalities. These data may have implications for the weight loss-independent management of cardiometabolic risk in pediatric populations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peso Corporal
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Comportamento de Redução do Risco
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Dietoterapia
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Terapia por Exercício
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Insulina
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Obesidade
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Am J Physiol Regul Integr Comp Physiol
Ano de publicação:
2013
Tipo de documento:
Article