The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
Am J Clin Exp Immunol
; 2(2): 172-85, 2013.
Article
em En
| MEDLINE
| ID: mdl-23885334
ABSTRACT
Vascular adhesion protein-1 (VAP-1) has been implicated in the pathogenesis of inflammatory diseases and is suggested to play a role in immune cell trafficking. It is not clear whether this effect is mediated by the oxidase activity or by other features of the protein such as direct adhesion. In order to study the role of VAP-1 oxidase activity in vivo, we have generated mice carrying an oxidase activity-null VAP-1 protein. We demonstrate that the VAP-1 oxidase null mutant mice have a phenotype similar to the VAP-1 null mice in animal models of sterile peritonitis and antibody induced arthritis suggesting that the oxidase activity is responsible for the inflammatory function of VAP-1.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Am J Clin Exp Immunol
Ano de publicação:
2013
Tipo de documento:
Article