[Vincristine-induced unilateral ptosis: case report and review of the literature]. / Ptosis unilatéral induit par la vincristine : à propos d'un cas et revue de la littérature.
J Fr Ophtalmol
; 36(8): 683-6, 2013 Oct.
Article
em Fr
| MEDLINE
| ID: mdl-23896211
ABSTRACT
We report the case of a 31-month-old girl, treated by the ifosfamide-vincristine-actinomycin chemotherapy protocol for vaginal rhabdomyosarcoma, who developed a unilateral left ptosis on day 36 of chemotherapy, i.e. 7 days after the fifth vincristine dose (1.5mg/m(2) or 0.90 mg). The cumulative vincristine dose was thus 4.50mg. The remainder of the neurological and systemic examinations were unremarkable. Laboratory testing and thoracic-cervical-cranial CT were normal. Other causes of ptosis were excluded. The ptosis decreased a few days after the infusion of vincristine and re-increased just after a new dose. It finally resolved upon lowering the dose of vincristine. According to our observations, the role of vincristine in the pathogenesis of this ptosis appears "likely". In such cases, maintenance of treatment is possible with adjustment of vincristine doses, but requires regular follow-up.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vincristina
/
Blefaroptose
Tipo de estudo:
Guideline
Limite:
Child, preschool
/
Female
/
Humans
Idioma:
Fr
Revista:
J Fr Ophtalmol
Ano de publicação:
2013
Tipo de documento:
Article