Epigallocatechin-3-gallate exerts protective effects against heat stress through modulating stress-responsive transcription factors in poultry.
Br Poult Sci
; 54(4): 447-53, 2013.
Article
em En
| MEDLINE
| ID: mdl-23906218
ABSTRACT
1. The aim of the study was to describe the effect of Epigallocatechin-3-gallate (EGCG), a polyphenol derived from green tea, on activator protein-1 (AP-1) components (phospho-c-Jun and c-Fos), cyclooxygenase-2 (COX-2) and heat shock proteins (HSPs) in the liver of heat-stressed quails. 2. A total of 180 5-week-old female Japanese quails were reared either at 22°C for 24 h/d (thermoneutral, TN) or 34°C for 8 h/d (heat stress, HS) for 12 weeks. Birds in both environments were randomly given 1 of 3 diets basal diet and basal diet with 200 or 400 mg of EGCG added per kilogram of diet. 3. The hepatic c-Jun, c-Fos, COX-2 and HSPs gene expression for quails reared under the HS environment was greater than those reared under the TN environment. Supplemental EGCG decreased hepatic expression of these proteins at a greater extent under HS than TN. 4. In conclusion, suppression of AP-1 COX-2 and HSPs may partly account for the inhibitory effect of EGCG in heat-stressed quail.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catequina
/
Resposta ao Choque Térmico
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Coturnix
/
Fígado
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Br Poult Sci
Ano de publicação:
2013
Tipo de documento:
Article