Gastrin-releasing peptide receptor signaling in the integration of stress and memory.
Neurobiol Learn Mem
; 112: 44-52, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24001571
ABSTRACT
Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin. GRP acts by binding to the GRP receptor (GRPR, also called BB2), a member of the G-protein coupled receptor (GPCR) superfamily. GRP produced by neurons in the central nervous system (CNS) plays a role in synaptic transmission by activating GRPRs located on postsynaptic membranes, influencing several aspects of brain function. Here we review the role of GRP/GRPR as a system mediating both stress responses and the formation and expression of memories for fearful events. GRPR signaling might integrate the processing of stress and fear with synaptic plasticity and memory, serving as an important component of the set of neurobiological systems underlying the enhancement of memory storage by aversive information.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
/
Transdução de Sinais
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Receptores da Bombesina
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Peptídeo Liberador de Gastrina
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Medo
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Memória
Limite:
Animals
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Humans
Idioma:
En
Revista:
Neurobiol Learn Mem
Ano de publicação:
2014
Tipo de documento:
Article