Eight years of growth hormone treatment in children with Prader-Willi syndrome: maintaining the positive effects.
J Clin Endocrinol Metab
; 98(10): 4013-22, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24001750
ABSTRACT
BACKGROUND:
The most important reason for treating children with Prader-Willi syndrome (PWS) with GH is to optimize their body composition.OBJECTIVES:
The aim of this ongoing study was to determine whether long-term GH treatment can counteract the clinical course of increasing obesity in PWS by maintaining the improved body composition brought during early treatment.SETTING:
This was a multicenter prospective cohort study.METHODS:
We have been following 60 prepubertal children for 8 years of continuous GH treatment (1 mg/m(2)/d ≈ 0.035 mg/kg/d) and used the same dual-energy x-ray absorptiometry machine for annual measurements of lean body mass and percent fat.RESULTS:
After a significant increase during the first year of GH treatment (P < .0001), lean body mass remained stable for 7 years at a level above baseline (P < .0001). After a significant decrease in the first year, percent fat SD score (SDS) and body mass index SDS remained stable at a level not significantly higher than at baseline (P = .06, P = .14, resp.). However, body mass index SDSPWS was significantly lower after 8 years of GH treatment than at baseline (P < .0001). After 8 years of treatment, height SDS and head circumference SDS had completely normalized. IGF-1 SDS increased to +2.36 SDS during the first year of treatment (P < .0001) and remained stable since then. GH treatment did not adversely affect glucose homeostasis, serum lipids, blood pressure, and bone maturation.CONCLUSION:
This 8-year study demonstrates that GH treatment is a potent force for counteracting the clinical course of obesity in children with PWS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Prader-Willi
/
Composição Corporal
/
Hormônio do Crescimento Humano
/
Obesidade
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Endocrinol Metab
Ano de publicação:
2013
Tipo de documento:
Article