Exploiting tertiary structure through local folds for crystallographic phasing.
Nat Methods
; 10(11): 1099-101, 2013 Nov.
Article
em En
| MEDLINE
| ID: mdl-24037245
ABSTRACT
We describe an algorithm for phasing protein crystal X-ray diffraction data that identifies, retrieves, refines and exploits general tertiary structural information from small fragments available in the Protein Data Bank. The algorithm successfully phased, through unspecific molecular replacement combined with density modification, all-helical, mixed alpha-beta, and all-beta protein structures. The method is available as a software implementation Borges.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estrutura Terciária de Proteína
/
Dobramento de Proteína
/
Cristalografia
Idioma:
En
Revista:
Nat Methods
Ano de publicação:
2013
Tipo de documento:
Article