Redefining the gut as the motor of critical illness.
Trends Mol Med
; 20(4): 214-23, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24055446
ABSTRACT
The gut is hypothesized to play a central role in the progression of sepsis and multiple organ dysfunction syndrome. Critical illness alters gut integrity by increasing epithelial apoptosis and permeability and by decreasing epithelial proliferation and mucus integrity. Additionally, toxic gut-derived lymph induces distant organ injury. Although the endogenous microflora ordinarily exist in a symbiotic relationship with the gut epithelium, severe physiological insults alter this relationship, leading to induction of virulence factors in the microbiome, which, in turn, can perpetuate or worsen critical illness. This review highlights newly discovered ways in which the gut acts as the motor that perpetuates the systemic inflammatory response in critical illness.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estado Terminal
/
Sepse
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Trato Gastrointestinal
/
Mucosa Intestinal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Mol Med
Ano de publicação:
2014
Tipo de documento:
Article