STAT2: A shape-shifting anti-viral super STAT.
JAKSTAT
; 2(1): e23633, 2013 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-24058798
ABSTRACT
STAT2 is unique among the STAT family of transcription factors in that its activation is driven predominantly by only two classes of cell surface receptors Type I and III interferon receptors. As such, STAT2 plays a critical role in host defenses against viral infections. Viruses have evolved to target STAT2 by either inhibiting its expression, blocking its activity, or by targeting it for degradation. Consequently, these viral onslaughts have driven remarkable divergence in the STAT2 gene across species that is not observed in other STAT family members. Thus, the evolution of STAT2 may preserve its activity and protect each species in the face of an ever-changing viral community.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
JAKSTAT
Ano de publicação:
2013
Tipo de documento:
Article