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Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors.
Lin, Tzung-Sheng; Liw, Ya-Wen; Song, Jen-Shin; Hsieh, Tsung-Chih; Yeh, Hsien-Wei; Hsu, Lih-Ching; Lin, Chun-Jung; Wu, Szu-Huei; Liang, Pi-Hui.
Afiliação
  • Lin TS; School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Bioorg Med Chem ; 21(21): 6282-91, 2013 Nov 01.
Article em En | MEDLINE | ID: mdl-24071445
ABSTRACT
Novel C-aryl-d-glucofuranosides were synthesized and evaluated for their capacity to inhibit human sodium-dependent glucose co-transporter 2 (hSGLT2) and hSGLT1. Compound 21q demonstrated the best in vitro inhibitory activity against SGLT2 in this series (EC50=0.62µM).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Benzidrílicos / Inibidores do Transportador 2 de Sódio-Glicose / Glucosidases / Glucosídeos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2013 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Benzidrílicos / Inibidores do Transportador 2 de Sódio-Glicose / Glucosidases / Glucosídeos Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Ano de publicação: 2013 Tipo de documento: Article