N-cadherin expression in feline mammary tumors is associated with a reduced E-cadherin expression and the presence of regional metastasis.
Vet Pathol
; 51(4): 755-8, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-24091815
ABSTRACT
The cadherin family of adhesion molecules regulates cell-cell interactions. N-cadherin is expressed by neural and fibroblast cells but not by normal epithelial cells. In human medicine, the role of N-cadherin in breast cancer remains controversial, but some studies have described the switch from E-cadherin to N-cadherin as a critical step in the malignant progression of neoplastic cells. The present study was carried out on 160 feline mammary tumors (21 adenomas and 139 carcinomas). The relationship between the immunohistochemical expression of N-cadherin in neoplastic epithelial cells and 2 established prognostic factors such as regional metastasis and tumor grade was examined. The results of the study showed a statistically significant relation between the expression of N-cadherin and the 2 prognostic factors, and also a reduced expression of E-cadherin in tumors that expressed N-cadherin.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças do Gato
/
Caderinas
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Regulação Neoplásica da Expressão Gênica
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Neoplasias Mamárias Animais
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Metástase Neoplásica
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Vet Pathol
Ano de publicação:
2014
Tipo de documento:
Article