Echoes of a distant past: The cag pathogenicity island of Helicobacter pylori.
Cold Spring Harb Perspect Med
; 3(11)2013 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-24097901
ABSTRACT
This review discusses the multiple roles of the CagA protein encoded by the cag pathogenicity island of Helicobacter pylori and highlights the CagA degradation activities on p53. By subverting the p53 tumor suppressor pathway CagA induces a strong antiapoptotic effect. Helicobacter pylori infection has been always associated with an increased risk of gastric cancer. The pro-oncogenic functions of CagA also target the tumor suppressor ASPP2. In the absence of tumor suppressor genes, cells survive and proliferate at times and in places where their survival and proliferation are inappropriate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
Helicobacter pylori
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Infecções por Helicobacter
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Antígenos de Bactérias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2013
Tipo de documento:
Article