Pd(II)-catalyzed ortho-trifluoromethylation of benzylamines.
Org Lett
; 15(20): 5258-61, 2013 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-24098966
ABSTRACT
The Pd(II)-catalyzed ortho-C-H trifluoromethylation of benzylamines has been achieved utilizing an electrophilic CF3 reagent. Additives, such as H2O and Ag2O, were found to be crucial for obtaining good yields. This protocol will be useful in medicinal chemistry for the preparation of ortho-trifluoromethyl-substituted benzylamines.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Paládio
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Benzilaminas
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2013
Tipo de documento:
Article