Interferon α/ß receptor knockout mice as a model to study bluetongue virus infection.
Virus Res
; 182: 35-42, 2014 Mar.
Article
em En
| MEDLINE
| ID: mdl-24100234
Bluetongue is an arthropod-borne disease caused by a virus of the genus Orbivirus, the bluetongue virus (BTV), which affects ruminant livestock such as cattle, sheep, and goats and wild ruminants such as deer, and camelids. Recently, adult mice with gene knockouts of the interferon α/ß receptor (IFNAR-/-) have been described as a model of lethal BTV infection. IFNAR(-/-) mice are highly susceptible to BTV-1, BTV-4 and BTV-8 infection when the virus is administered intravenously or subcutaneosuly. Disease progression and pathogenesis closely mimics signs of bluetongue disease in ruminants. In the present paper we review the studies where IFNAR(-/-) mice have been used as an animal model to study BTV transmission, pathogenesis, virulence, and protective efficacy of inactivated and new recombinant marker BTV vaccines. Furthermore, we report new data on protective efficacy of different strategies of BTV vaccination and also on induction of interferon α/ß and proinflammatory immune responses in IFNAR(-/-) mice infected with BTV.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
Base de dados:
MEDLINE
Assunto principal:
Bluetongue
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Vírus Bluetongue
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Modelos Animais de Doenças
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Receptor de Interferon alfa e beta
Limite:
Animals
Idioma:
En
Revista:
Virus Res
Ano de publicação:
2014
Tipo de documento:
Article