[Stem cell therapy and tissue engineering in regenerative urology]. / Stammzelltherapie und "Tissue Engineering" in der regenerativen Urologie.
Urologe A
; 52(12): 1671-8, 2013 Dec.
Article
em De
| MEDLINE
| ID: mdl-24166059
ABSTRACT
BACKGROUND:
So far there is no clinically established, effective tissue engineering therapy for dysfunction or defects of the lower urinary tract. The concentration of experimental data, initial clinical studies and individual case reports underlines that stem cell treatment for bladder storage and voiding problems, erectile dysfunction and other urothelial defects of the lower urinary tract could close the gap between individualized therapy and potential biomedical applications.RESULTS:
As a result of fundamental research work over the last decade a characterization of various stem cell populations and evaluation of different urological therapy options could be performed. Thereby, aspects of optimal administration, migration, secretion of bioactive factors and stage of differentiation of stem cells with respect to an improved efficiency of treatment were investigated. Because successful tissue regeneration depends on angiogenesis and innervation, particular attention was paid to these important factors.CONCLUSIONS:
Various clinical indications for stem cell treatment and tissue reconstruction that may be required after radical prostatectomy, such as stress urinary incontinence, urethral reconstruction and erectile dysfunction have materialized and are currently being verified in preclinical studies and phase I trials.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Urológicas
/
Urologia
/
Engenharia Tecidual
/
Transplante de Células-Tronco
/
Medicina Regenerativa
Limite:
Humans
Idioma:
De
Revista:
Urologe A
Ano de publicação:
2013
Tipo de documento:
Article