Vitamin D status and its association with antioxidant profiles in diabetic patients: A cross-sectional study in Iran.

ABSTRACT

BACKGROUND AND OBJECTIVES: There are increasing evidences about the relationship between vitamin D status and the control of diabetes. Several studies showed that vitamin D has an antioxidant property. In this study, we aimed to determine the relationship between serum levels of 25-hydroxy vitamin D (25-OH-D) and glycemic, antioxidant profile in diabetes compared to healthy groups. MATERIALS AND METHODS: This cross-sectional study was conducted in 100 patients with type 2 diabetes mellitus (T2DM) and 100 healthy controls. Fasting serum levels of 25-OH-D, calcium, phosphorous, parathyroid hormone, glucose, HbA(1C), insulin, homeostasis model assessment of insulin resistance index, total antioxidant capacity (TAC), activities of superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GSH-PX) were measured. RESULTS: Eighty-two percent of type 2 diabetic patients and 75% of healthy subjects were suffering from vitamin D deficiency or insufficiency. The activities of GR and GSH-PX were higher in diabetic patients compared to control. There was a negative relationship between 25-OH-D and activity of GR, GSH-PX. Also, 25-OH-D had a positive association with activity of SOD in diabetic patients. In the control group, 25-OH-D had an inverse relationship with SOD, GSH-PX, and positively with GR activities. INTERPRETATION AND CONCLUSIONS: Vitamin D deficiency has a high prevalence among Iranian adult population with and without type 2 diabetes. Our results showed that vitamin D may have a beneficial effect on the control of glycemic profiles and oxidative stress in T2DM patients.