Knockdown of p66Shc by siRNA injection rescues arsenite-induced developmental retardation in mouse preimplantation embryos.

Ren, Kai; Li, Xiaoqiao; Yan, Jinting; Huang, Guoying; Zhou, Shiyi; Yang, Baiqing; Ma, Xu; Lu, Cailing

Ren, Kai; Li, Xiaoqiao; Yan, Jinting; Huang, Guoying; Zhou, Shiyi; Yang, Baiqing; Ma, Xu; Lu, Cailing.

Afiliação

Ren K; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China.
Li X; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China.
Yan J; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China.
Huang G; Children's Hospital of Fudan University, Shanghai, China.
Zhou S; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China.
Yang B; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China.
Ma X; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China. Electronic address: genetic@263.net.cn.
Lu C; Graduate School of Peking Union Medical College, Beijing, China; Department of Genetics, National Research Institute for Family Planning, Beijing, China; World Health Organizations Collaborative Center for Research in Human Reproduction, Beijing, China. Electronic address: lucailing@sina.com.

Reprod Toxicol ; 43: 8-18, 2014 Jan.

Article em En | MEDLINE | ID: mdl-24184494

Assuntos

Arsenitos/toxicidade; Blastocisto/efeitos dos fármacos; Desenvolvimento Embrionário; Proteínas Adaptadoras da Sinalização Shc/genética; Compostos de Sódio/toxicidade; Animais; Blastocisto/metabolismo; Desenvolvimento Embrionário/efeitos dos fármacos; Desenvolvimento Embrionário/fisiologia; Feminino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Endogâmicos DBA; Estresse Oxidativo; Gravidez; RNA Interferente Pequeno/genética; Espécies Reativas de Oxigênio/metabolismo; Proteínas Adaptadoras da Sinalização Shc/metabolismo; Proteína 1 de Transformação que Contém Domínio 2 de Homologia de Src

Palavras-chave

Arsenite; Embryo arrest; Pronuclear microinjection; Reactive oxygen species; p66(Shc); siRNA

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Blastocisto / Compostos de Sódio / Arsenitos / Desenvolvimento Embrionário / Proteínas Adaptadoras da Sinalização Shc Limite: Animals / Pregnancy Idioma: En Revista: Reprod Toxicol Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google