Comparative efficacy of Lamivudine and emtricitabine: a systematic review and meta-analysis of randomized trials.
PLoS One
; 8(11): e79981, 2013.
Article
em En
| MEDLINE
| ID: mdl-24244586
ABSTRACT
INTRODUCTION:
Lamivudine and emtricitabine are considered equivalent by several guidelines, but evidence of comparable efficacy is conflicting.METHODS:
We searched two databases up to June 30 2013 to identify randomized and quasi-randomized trials in which lamivudine and emtricitabine were used as part of combination antiretroviral therapy for treatment-naïve or experienced HIV-positive adult patients. We only included trials where partner drugs in the regimen were identical or could be considered to be comparable. We allowed for comparisons between tenofovir and abacavir provided the study population did not begin treatment with a viral load >100,000 copies/ml.RESULTS:
12 trials contributed 15 different randomized comparisons providing data on 2251 patients receiving lamivudine and 2662 patients receiving emtricitabine. Treatment success was not significantly different in any of the 12 trials. In the three trials that directly compared lamivudine and emtricitabine, the relative risk for achieving treatment success was non-significant (RR 1.03 95%CI 0.96-1.10). For all trials combined, the pooled relative risk for treatment success was not significantly different (RR 1.00, 95%CI 0.97-1.02). No heterogeneity was observed (I (2) = 0). Similarly, there was no difference in the pooled relative risk for treatment failure (RR 1.08, 95%CI 0.94-1.22, I (2) = 3.4%).CONCLUSIONS:
The findings of this systematic review suggest that lamivudine and emtricitabine are clinically equivalent.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
HIV-1
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Inibidores da Transcriptase Reversa
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Lamivudina
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Fármacos Anti-HIV
/
Desoxicitidina
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Guideline
/
Prognostic_studies
/
Systematic_reviews
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
PLoS One
Ano de publicação:
2013
Tipo de documento:
Article