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Take five - Type VII secretion systems of Mycobacteria.
Houben, Edith N G; Korotkov, Konstantin V; Bitter, Wilbert.
Afiliação
  • Houben EN; VU University, Amsterdam, The Netherlands; VU University Medical Center, Amsterdam, The Netherlands. Electronic address: e.n.g.houben@vu.nl.
  • Korotkov KV; University of Kentucky, Lexington, KY, USA.
  • Bitter W; VU University, Amsterdam, The Netherlands; VU University Medical Center, Amsterdam, The Netherlands.
Biochim Biophys Acta ; 1843(8): 1707-16, 2014 Aug.
Article em En | MEDLINE | ID: mdl-24263244
Mycobacteria use type VII secretion (T7S) systems to secrete proteins across their complex cell envelope. Pathogenic mycobacteria, such as the notorious pathogen Mycobacterium tuberculosis, have up to five of these secretion systems, named ESX-1 to ESX-5. At least three of these secretion systems are essential for mycobacterial virulence and/or viability. Elucidating T7S is therefore essential to understand the success of M. tuberculosis and other pathogenic mycobacteria as pathogens, and could be instrumental to identify novel targets for drug- and vaccine-development. Recently, significant progress has been achieved in the identification of T7S substrates and a general secretion motif. In addition, a start has been made with unraveling the mechanism of secretion and the structural analysis of the different subunits. This review summarizes these recent findings, which are incorporated in a working model of this complex machinery. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Transporte Proteico / Sistemas de Secreção Bacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Transporte Proteico / Sistemas de Secreção Bacterianos / Mycobacterium tuberculosis Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochim Biophys Acta Ano de publicação: 2014 Tipo de documento: Article