Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors.
Dalton Trans
; 43(13): 4941-4, 2014 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-24270971
ABSTRACT
Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration-dependent manner without affecting HIF-1α mRNA expression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos de Boro
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
Limite:
Humans
Idioma:
En
Revista:
Dalton Trans
Ano de publicação:
2014
Tipo de documento:
Article