Immunomodulating effect of ethyl pyruvate on nonsyngenic transplanted tumor in mice.
Bull Exp Biol Med
; 155(6): 785-7, 2013 Oct.
Article
em En
| MEDLINE
| ID: mdl-24288766
ABSTRACT
Indolamine-2,3-dioxygenase, a tryptophan-catabolizing enzyme, creates local conditions suppressing immune lymphocytes. Expression of this enzyme in tumors protects them from immune mechanisms, while its inhibition partially reduces tumor immunoresistance. This effect is attained by multiple subcutaneous or intraperitoneal injections of ethyl pyruvate, an indolamine-2,3-dioxygenase inhibitor. Experiments on mouse nonsyngenic tumor have demonstrated the immunomodulating effect of chronic oral ethyl pyruvate administered with drinking water.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piruvatos
/
Fatores Imunológicos
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2013
Tipo de documento:
Article