Inhibition of proinflammatory cytokine by IL-25 in Vogt-Koyanagi-Harada syndrome.
Ocul Immunol Inflamm
; 22(4): 294-9, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24329541
ABSTRACT
PURPOSE:
Vogt-Koyanagi-Harada (VKH) syndrome is a multisystem disorder presumed to be mediated by an autoimmune response. Recent studies have shown that interleukin (IL) 25 was involved in the T-cell immune response. This study analyzed the expression and potential role of IL-25 in the pathogenesis of VKH syndrome.METHODS:
The IL-25 serum levels were determined by enzyme-linked immunosorbent assay (ELISA). The IL-1ß, IL-6, and TNF-α level in supernatants of PBMCs cultured with LPS in the absence or presence of recombinant(r) IL-25 was detected by ELISA.RESULTS:
A significantly decreased serum IL-25 level was found in VKH patients. In vitro experiments showed that rIL-25 was able to significantly inhibit the production of IL-1ß, IL-6, and TNF-α by PBMCs from active VKH patients.CONCLUSIONS:
IL-25 may be involved in the development of VKH syndrome, possibly by inhibiting the expression of proinflammatory cytokines.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome Uveomeningoencefálica
/
Interleucina-17
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Ocul Immunol Inflamm
Ano de publicação:
2014
Tipo de documento:
Article