What would be the most appropriate α/ß ratio in the setting of stereotactic body radiation therapy for early stage non-small cell lung cancer.
Biomed Res Int
; 2013: 391021, 2013.
Article
em En
| MEDLINE
| ID: mdl-24350266
ABSTRACT
We hypothesize that the correlation between the radiation dose expressed as the biologically effective dose (BED) and the clinical endpoints will correlate better as the value of the α/ß ratio is increased to >10 Gy, which theoretically minimizes the overestimation of the dose potency associated with the linear quadratic (LQ) formula in the setting of stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). A search was conducted in the PubMed electronic databases in August 2011. In the studies analyzed, increasing the α/ß ratio is associated with an increase in the strength of the correlation between isocenter BED and local control, especially in the studies with median followup of ≥24 months, for which Spearman's correlation coefficients of 0.74-0.76 were achieved for α/ß of 20 Gy, 30 Gy, and 50 Gy (P = 0.007-0.008). A trend toward statistical significance was observed for the correlation of isocenter BED and the 2-year overall survival when an α/ß of 20 Gy was used approached statistical significance (P = 0.073). Our results suggest that an α/ß > 10 Gy may be more appropriate for the prediction of dose response in the setting of lung SBRT.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
6_ODS3_enfermedades_notrasmisibles
Base de dados:
MEDLINE
Assunto principal:
Radiocirurgia
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Revista:
Biomed Res Int
Ano de publicação:
2013
Tipo de documento:
Article