The Liverpool uveal melanoma liver metastases pathway: outcome following liver resection.
J Surg Oncol
; 109(6): 542-7, 2014 May.
Article
em En
| MEDLINE
| ID: mdl-24357463
ABSTRACT
AIM:
To determine the outcome of patients that underwent liver resection for metastases from uveal melanoma.METHODS:
Over a 9-year period, patients referred with uveal melanoma metastases were included. Following treatment of primary uveal melanoma, high-risk patients were offered to be enrolled into a 6-monthly non-contrast liver magnetic resonance imaging (MRI) surveillance. Following detection of liver metastases, patients were staged with a contrast-enhanced (Primovist(®)) liver MRI, computer tomography (CT) of the thorax and staging laparoscopy.RESULTS:
155 patients were referred with uveal melanoma liver metastases, of which 17 (11.0%) patients had liver resection and one patient was treated with percutaneous radio-frequency ablation. The majority of patients undergoing liver resection were treated with multiple metastectomies (n = 8) and three patients had major liver resections. The overall median survival for patients treated with surgery/ablation was 27 (14-90) months, and this was significantly better compared to patients treated palliatively [median = 8(1-30) months, P < 0.001]. Following surgery, 11 patients had recurrent disease [median = 13(6-36) months]. Patients who had undergone a major liver resection had a significantly poorer disease-free survival (P = 0.037).CONCLUSIONS:
Patients who can undergo surgical resection for metastatic uveal melanoma have a more favorable survival compared to those who do not.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Uveais
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Hepatectomia
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Neoplasias Hepáticas
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Melanoma
Tipo de estudo:
Screening_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Surg Oncol
Ano de publicação:
2014
Tipo de documento:
Article