Genomic insights into WNT/ß-catenin signaling.
Trends Pharmacol Sci
; 35(2): 103-9, 2014 Feb.
Article
em En
| MEDLINE
| ID: mdl-24365576
ABSTRACT
The canonical WNT pathway regulates the stability of the proto-oncogene ß-catenin and is aberrantly activated in many cancer types. Studies in a wide range of experimental models confirm that ß-catenin activity is required for tumor initiation in cancers where this pathway is deregulated. However, to date this pathway has proven to be challenging to target therapeutically. Moreover, several lines of evidence suggest that other components and regulators of ß-catenin exist. Here we will describe recent structural and functional studies describing genomic alterations and new regulators of ß-catenin that lead to aberrant activation of the WNT/ß-catenin pathway. These findings provide new insights into the biology of WNT/ß-catenin signaling and suggest potential therapeutic opportunities.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Wnt
/
Beta Catenina
/
Via de Sinalização Wnt
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Pharmacol Sci
Ano de publicação:
2014
Tipo de documento:
Article