A male patient who developed late-onset primary biliary cirrhosis presenting with antinuclear envelope antibodies.
Mod Rheumatol
; 12(3): 246-9, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-24387066
ABSTRACT
Abstract An 81-year-old man who had previously shown high levels of alkaline phosphatase (ALP), γ-glutamyltransferase (GTP), and total bilirubin presented with acute liver damage. He was positive for serum anti-gp210 and anti-p62 antibodies, but negative for serum antimitochondrial antibody. A liver biopsy revealed massive interstitial fibrosis and pseudolobulus, which were compatible with a diagnosis of primary biliary cirrhosis (PBC) at Scheuer's stage 4. He was given ursodeoxycolic acid at 600 mg/day. However, his condition deteriorated, and he eventually died of hepatic insufficiency in a state of malnutrition. We hypothesize that the presence of anti-gp210 and anti-p62 complex protein antibodies, rather than that of antimitochondrial antibodies, was correlated with the progression of PBC in this particular case.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mod Rheumatol
Ano de publicação:
2002
Tipo de documento:
Article