Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-&#945;: the role of PKC-ß2 and NADPH oxidase.

Lei, Shaoqing; Su, Wating; Liu, Huimin; Xu, Jinjin; Xia, Zhong-yuan; Yang, Qing-jun; Qiao, Xin; Du, Yun; Zhang, Liangqing; Xia, Zhengyuan

Nitroglycerine-induced nitrate tolerance compromises propofol protection of the endothelial cells against TNF-α: the role of PKC-ß2 and NADPH oxidase.

Lei, Shaoqing; Su, Wating; Liu, Huimin; Xu, Jinjin; Xia, Zhong-yuan; Yang, Qing-jun; Qiao, Xin; Du, Yun; Zhang, Liangqing; Xia, Zhengyuan.

Afiliação

Lei S; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China ; Department of Anesthesiology, University of Hong Kong, Hong Kong.
Su W; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Liu H; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China ; Department of Anesthesiology, University of Hong Kong, Hong Kong.
Xu J; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Xia ZY; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Yang QJ; Department of Cardiac Surgery, Chongqing Zhongshan Hospital, Chongqing 400013, China.
Qiao X; Department of Anesthesia, Chongqing Zhongshan Hospital, Chongqing 400013, China.
Du Y; Department of Anesthesia, Chongqing Zhongshan Hospital, Chongqing 400013, China.
Zhang L; Department of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, China.
Xia Z; Department of Anesthesiology, University of Hong Kong, Hong Kong ; Department of Anesthesiology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, China.

Oxid Med Cell Longev ; 2013: 678484, 2013.

Article em En | MEDLINE | ID: mdl-24396568

Assuntos

Células Endoteliais da Veia Umbilical Humana/enzimologia; NADPH Oxidases/metabolismo; Nitratos/farmacologia; Nitroglicerina/farmacologia; Propofol/farmacologia; Proteína Quinase C beta/metabolismo; Fator de Necrose Tumoral alfa/farmacologia; Apoptose/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Citoproteção/efeitos dos fármacos; Citometria de Fluxo; Células Endoteliais da Veia Umbilical Humana/citologia; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Humanos; L-Lactato Desidrogenase/metabolismo; Malondialdeído/metabolismo; Nitritos/metabolismo; Ftalimidas/farmacologia; Superóxidos/metabolismo; Tirosina/análogos & derivados; Tirosina/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propofol / Fator de Necrose Tumoral alfa / Nitroglicerina / NADPH Oxidases / Células Endoteliais da Veia Umbilical Humana / Proteína Quinase C beta / Nitratos Limite: Humans Idioma: En Revista: Oxid Med Cell Longev Ano de publicação: 2013 Tipo de documento: Article

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