Genome-wide unmasking of epigenetically silenced genes in lung adenocarcinoma from smokers and never smokers.

Tessema, Mathewos; Yingling, Christin M; Liu, Yushi; Tellez, Carmen S; Van Neste, Leander; Baylin, Stephen S; Belinsky, Steven A

Tessema, Mathewos; Yingling, Christin M; Liu, Yushi; Tellez, Carmen S; Van Neste, Leander; Baylin, Stephen S; Belinsky, Steven A.

Afiliação

Tessema M; Department of Lung Cancer, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA, MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and Departm
Yingling CM; Department of Lung Cancer, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA, MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and Departm
Liu Y; Department of Lung Cancer, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA, MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and Departm
Tellez CS; Department of Lung Cancer, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA, MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and Departm
Van Neste L; MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and.
Baylin SS; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.
Belinsky SA; Department of Lung Cancer, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA, MDxHealth Inc., Irvine, CA 92618, USA, Department of Pathology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands and Departm

Carcinogenesis ; 35(6): 1248-57, 2014 Jun.

Article em En | MEDLINE | ID: mdl-24398667

Assuntos

Adenocarcinoma/genética; Epigênese Genética; Regulação Neoplásica da Expressão Gênica; Inativação Gênica; Neoplasias Pulmonares/genética; Fumar; Adenocarcinoma/mortalidade; Adenocarcinoma/patologia; Azacitidina/análogos & derivados; Azacitidina/farmacologia; Linhagem Celular Tumoral; Ilhas de CpG; Metilação de DNA; Decitabina; Progressão da Doença; Epigênese Genética/efeitos dos fármacos; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Estudo de Associação Genômica Ampla; Humanos; Neoplasias Pulmonares/mortalidade; Neoplasias Pulmonares/patologia; Regiões Promotoras Genéticas; Reprodutibilidade dos Testes

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Fumar / Regulação Neoplásica da Expressão Gênica / Inativação Gênica / Epigênese Genética / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Carcinogenesis Ano de publicação: 2014 Tipo de documento: Article

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