Simulation of voltage-driven hydrated cation transport through narrow transmembrane channels.
Biophys J
; 51(6): 977-83, 1987 Jun.
Article
em En
| MEDLINE
| ID: mdl-2440486
ABSTRACT
Molecular dynamics studies for the voltage-driven transport of the alkali metal ions lithium, sodium, and potassium through gramicidin A-type channels filled with water molecules are presented. The number of water molecules in the channel is obtained from a previous study (Skerra, A., and J. Brickmann, 1987, Biophys. J., 51969-976). It is shown that the selectivity of the intrachannel ion diffusion through our model pore conforms to the experimentally observed selectivity of the gramicidin A channel. It is demonstrated that the number of water molecules in the channel plays a key role for the selectivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gramicidina
/
Canais Iônicos
/
Modelos Biológicos
Idioma:
En
Revista:
Biophys J
Ano de publicação:
1987
Tipo de documento:
Article