Recent progress in the discovery and development of N-type calcium channel modulators for the treatment of pain.
Prog Med Chem
; 53: 147-86, 2014.
Article
em En
| MEDLINE
| ID: mdl-24418610
ABSTRACT
The importance of voltage-gated calcium channels (VGCCs) in basic physiological processes such as cardiac and neurological function has generated intense interest in these proteins as targets of pharmacological intervention. N-type calcium channels are a subset of VGCCs distinguished by their physiology, pharmacology and significance to the pathology of chronic pain. Despite decades of investigation, only a single drug targeting N-type channel function has entered the marketplace. This review will summarize our current understanding of the biology, physiology and pharmacology of N-type calcium channels and the implication of these features for therapeutic intervention. From this basis of understanding, recent efforts to discover and develop peptide based and small molecule modulators of N-type calcium channel function will be discussed.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Canais de Cálcio Tipo N
/
Descoberta de Drogas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Prog Med Chem
Ano de publicação:
2014
Tipo de documento:
Article