Susceptibility of openbill storks (Anastomius oscitans) to highly pathogenic avian influenza virus subtype H5N1.
Southeast Asian J Trop Med Public Health
; 44(5): 799-809, 2013 Sep.
Article
em En
| MEDLINE
| ID: mdl-24437315
ABSTRACT
This investigation detailed the clinical disease, gross and histologic lesions in juvenile openbill storks (Anastomus oscitans) intranasally inoculated with an avian influenza virus, A/chicken/Thailand/vsmu-3 (H5N1), which is highly pathogenic for chickens. High morbidity and mortality were observed in openbill storks inoculated with HPAI H5N1 virus. Gross lesions from infected birds were congestion and brain hemorrhage (10/20), pericardial effusions, pericarditis and focal necrosis of the cardiac muscle (2/20), pulmonary edema and pulmonary necrosis, serosanguineous fluid in the bronchis (16/20), liver congestion (6/20), bursitis (5/20), subcutaneous hemorrhages (2/20) and pinpoint proventiculus hemorrhage (2/20). Real time RT-PCR demonstrated the presence of viral RNA in organs associated with the lesions brain, trachea, lungs, liver, spleen and intestines. Similar to viral genome detection, virus was also isolated from these vital organs. Antibodies to influenza virus detected with a hemagglutination inhibition test, were found only in the openbill storks who died 8 days post-inoculation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Virus da Influenza A Subtipo H5N1
/
Influenza Aviária
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Southeast Asian J Trop Med Public Health
Ano de publicação:
2013
Tipo de documento:
Article