Major histocompatibility complex and inflammatory cell subtype expression in inflammatory myopathies and muscular dystrophies.
Neurol India
; 61(6): 614-21, 2013.
Article
em En
| MEDLINE
| ID: mdl-24441329
ABSTRACT
BACKGROUND:
In inflammatory myopathies muscle biopsy is a crucial diagnostic test. Misinterpretation between inflammatory myopathies and muscular dystrophies with inflammation is known. MATERIALS ANDMETHODS:
Thirty-one patients clinically and pathologically diagnosed to have polymyositis and dermatomyositis and 16 patients of muscular dystrophy with inflammation were studied for MHC-I, MHC-II, CD4 and CD8 expression in skeletal muscle tissue.RESULTS:
MHC-I upregulation was noted in all samples of PM and DM. Interstitial and perivascular inflammation in PM were predominantly CD8+ cells, in dermatomyositis, interstitial and perimysial perivascular inflammatory cells were CD4+ T cells and CD8+ T cells were seen around endomysial vessels. Interestingly MHC-I upregulation was seen in all 16 cases of muscular dystrophy with presence of inflammation.CONCLUSION:
The pattern of MHC-I and II expression appeared to be similar in both inflammatory myopathies as well as in muscular dystrophies with inflammation and hence differentiating them on MHC - I expression was difficult.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complexo Principal de Histocompatibilidade
/
Distrofias Musculares
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Miosite
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Neurol India
Ano de publicação:
2013
Tipo de documento:
Article