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The central role of EED in the orchestration of polycomb group complexes.
Cao, Qi; Wang, Xiaoju; Zhao, Meng; Yang, Rendong; Malik, Rohit; Qiao, Yuanyuan; Poliakov, Anton; Yocum, Anastasia K; Li, Yong; Chen, Wei; Cao, Xuhong; Jiang, Xia; Dahiya, Arun; Harris, Clair; Feng, Felix Y; Kalantry, Sundeep; Qin, Zhaohui S; Dhanasekaran, Saravana M; Chinnaiyan, Arul M.
Afiliação
  • Cao Q; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Center for Inflammation and Epigenetics, Houston Methodist Research Institute,
  • Wang X; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Zhao M; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30329, USA.
  • Yang R; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30329, USA.
  • Malik R; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Qiao Y; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Poliakov A; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Yocum AK; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Li Y; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Chen W; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Cao X; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Jiang X; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Dahiya A; Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Harris C; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Feng FY; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Comprehensive Cancer Center, University of Michigan Medical School, An
  • Kalantry S; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Qin ZS; 1] Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30329, USA [2] Center for Comprehensive Informatics, Emory University, Atlanta, Georgia 30329, USA.
  • Dhanasekaran SM; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
  • Chinnaiyan AM; 1] Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [2] Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA [3] Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arb
Nat Commun ; 5: 3127, 2014.
Article em En | MEDLINE | ID: mdl-24457600
ABSTRACT
Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions as part of PRC1. Components of PRC1 and PRC2 compete for EED binding. EED functions to recruit PRC1 to H3K27me3 loci and enhances PRC1-mediated H2A ubiquitin E3 ligase activity. Taken together, we suggest an integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 and 2.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Grupo Polycomb / Complexo Repressor Polycomb 2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Ano de publicação: 2014 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas do Grupo Polycomb / Complexo Repressor Polycomb 2 Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Ano de publicação: 2014 Tipo de documento: Article