Effect of immunotherapy on the response of TICLs to solid tumour invasion.

ABSTRACT

There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction of TICLs with tumour cells, with and without clinical intervention. Stability analysis and numerical simulations of the models reveal the existence of a stable tumour dormant state.