Protective effect of leflunomide against oxidative intestinal injury in a rodent model of sepsis.
J Surg Res
; 187(2): 610-5, 2014 Apr.
Article
em En
| MEDLINE
| ID: mdl-24484905
ABSTRACT
BACKGROUND:
Sepsis is defined as an uncontrolled inflammatory response in a host. The process may lead to severe sepsis, multisystem organ failure and even death. Leflunomide has important immunomodulatory and anti-inflammatory effects, which may mitigate host response to bacterial translocation. The goal of our study was to measure the effects leflunomide administration had on a variety of biochemical markers upregulated in systemic inflammatory response syndrome, sepsis, and multiple organ failure syndrome. MATERIALS ANDMETHODS:
Wistar albino type rats were randomly divided into five groups control, sham, leflunomide, sepsis, and sepsis + leflunomide. Sepsis was achieved by means of the cecal ligation and puncture method. Leflunomide 2 × 10 mg/kg/d was administered before the experiment. At the end of 24 h, the tissue levels of superoxide dismutase, catalase activity, malondialdehyde, nitric oxide, and protein carbonyl were measured.RESULTS:
The level of the bowel superoxide dismutase and catalase levels of the sepsis group is significantly lower than those of the control, sham, and leflunomide groups (P < 0.05). Malondialdehyde, nitric oxide, and protein carbonyl levels are significantly higher in sepsis compared with other groups (P < 0.05).CONCLUSIONS:
Leflunomide's prevention of protein and lipid peroxidation was observed in septic bowel tissue. Use of leflunomide could have protective effects against both the onset and the progressive stages of sepsis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anti-Inflamatórios não Esteroides
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Sepse
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Estresse Oxidativo
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Isoxazóis
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Insuficiência de Múltiplos Órgãos
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Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
J Surg Res
Ano de publicação:
2014
Tipo de documento:
Article