Back to bases: how a nucleotide biosynthetic enzyme controls p53 activation.

Guarnieri, Anna L; Espinosa, Joaquín M

Guarnieri, Anna L; Espinosa, Joaquín M.

Afiliação

Guarnieri AL; Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA.
Espinosa JM; Howard Hughes Medical Institute and Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, CO 80309, USA. Electronic address: joaquin.espinosa@colorado.edu.

Mol Cell ; 53(3): 365-7, 2014 Feb 06.

Article em En | MEDLINE | ID: mdl-24507714

ABSTRACT

ABSTRACT

In this issue, Reddy et al. (2014) reveal a new twist in the molecular mechanism leading to p53 activation upon cellular stress, illuminating an unexpected nuclear role for a nucleotide biosynthetic enzyme in regulation of a potent tumor suppressor.

Assuntos

Carbono-Nitrogênio Ligases/fisiologia; Nucleotídeos/biossíntese; Ribonucleoproteínas/fisiologia; Proteína Supressora de Tumor p53/metabolismo; Animais; Feminino; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleoproteínas / Proteína Supressora de Tumor p53 / Carbono-Nitrogênio Ligases / Nucleotídeos Limite: Animals / Female / Humans Idioma: En Revista: Mol Cell Ano de publicação: 2014 Tipo de documento: Article

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